- Original Article
- The neuroprotective effect of mycophenolic acid via anti-apoptosis in perinatal hypoxic-ischemic brain injury
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Ji Young Kim, Seung Ho Yang, Sun Hwa Cha, Ji Yeun Kim, Young Chae Jang, Kwan Kyu Park, Jin Kyung Kim, Hai Lee Chung, Eok Su Seo, Woo Taek Kim
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Clin Exp Pediatr. 2007;50(7):686-693. Published online July 15, 2007
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Purpose : Mycophenolic acid (MPA), the active metabolite of mycophenolate mofetil (MMF), is a potent inhibitor of inosine-monophosphate dehydrogenase (IMPDH), a new immunosuppressive drug used. It was reported that MPA protected neurons after excitotoxic injury, induced apoptosis in microglial cells. However, the effects of MPA on hypoxic-ischemic (HI) brain injury has not been yet evaluated. Therefore, we examined whether MPA... |
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